Letter is 8.5 × 11 inches, or 216 × 279 mm. It is the paper in almost every printer in North America, which makes it the practical choice for a home-printed poster even though the A series tiles more tidily.
The difference is worth knowing. A4 halves cleanly, so A4 tilings land on standard frame sizes. Letter does not: two sheets across in portrait gives 17 inches of width, three gives 25.5, four gives 34. Those are close to but not exactly the common US poster sizes of 18 × 24 and 24 × 36 inches. If you are printing for a standard frame, aim slightly over and trim the outer edge.
A 4000 × 3000 photo across two Letter portrait sheets comes to 6 sheets (3 across × 2 down). In landscape the same picture comes to 9 sheets (3 across × 3 down), which is usually fewer sheets for a wide image.
If you have Legal or Tabloid in the drawer, both are supported and both cut down the number of joins. Legal is 8.5 × 14 inches, the same width as Letter with more length. Tabloid is 11 × 17 inches, which is two Letter sheets in one, and it halves the join count for the same finished size.
Overlap, cut marks, sheet numbering and the effective dpi are all shown before you export. The PDF is generated in your browser and nothing is uploaded.